4f2a
From Proteopedia
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{{STRUCTURE_4f2a| PDB=4f2a | SCENE= }} | {{STRUCTURE_4f2a| PDB=4f2a | SCENE= }} | ||
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===Crystal structure of cholestryl esters transfer protein in complex with inhibitors=== | ===Crystal structure of cholestryl esters transfer protein in complex with inhibitors=== | ||
| + | {{ABSTRACT_PUBMED_22961980}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:[http://omim.org/entry/143470 143470]]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).<ref>PMID:2215607</ref><ref>PMID:8408659</ref><ref>PMID:12091484</ref> | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. | ||
==About this Structure== | ==About this Structure== | ||
[[4f2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2A OCA]. | [[4f2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2A OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Liu, S.]] | [[Category: Liu, S.]] | ||
Revision as of 06:06, 25 March 2013
Contents |
Crystal structure of cholestryl esters transfer protein in complex with inhibitors
Template:ABSTRACT PUBMED 22961980
Disease
[CETP_HUMAN] Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).[1][2][3]
Function
[CETP_HUMAN] Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.
About this Structure
4f2a is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Inazu A, Brown ML, Hesler CB, Agellon LB, Koizumi J, Takata K, Maruhama Y, Mabuchi H, Tall AR. Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. N Engl J Med. 1990 Nov 1;323(18):1234-8. PMID:2215607 doi:http://dx.doi.org/10.1056/NEJM199011013231803
- ↑ Takahashi K, Jiang XC, Sakai N, Yamashita S, Hirano K, Bujo H, Yamazaki H, Kusunoki J, Miura T, Kussie P, et al.. A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins. J Clin Invest. 1993 Oct;92(4):2060-4. PMID:8408659 doi:http://dx.doi.org/10.1172/JCI116802
- ↑ Nagano M, Yamashita S, Hirano K, Ito M, Maruyama T, Ishihara M, Sagehashi Y, Oka T, Kujiraoka T, Hattori H, Nakajima N, Egashira T, Kondo M, Sakai N, Matsuzawa Y. Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay. J Lipid Res. 2002 Jul;43(7):1011-8. PMID:12091484
