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1f5u

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[[Image:1f5u.png|left|200px]]
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==SOLUTION STRUCTURE OF THE KISSING DIMER OF H3 GACG STEM-LOOP IN THE 5'-END DIMERIZATION SIGNAL OF MOLONEY MURINE LEUKEMIA VIRUS GENOMIC RNA==
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<StructureSection load='1f5u' size='340' side='right' caption='[[1f5u]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1f5u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F5U FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f5u RCSB], [http://www.ebi.ac.uk/pdbsum/1f5u PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The dimerization of viral RNA through noncovalent interactions at their 5' ends is a key step in the life cycle of retroviruses. In Moloney murine leukemia virus, three stem-loops are important in this process. One is a self-complementary tetraloop (H1), but the other two stem-loops (H2, H3) contain highly conserved GACG tetraloops that are not self-complementary sequences. Using two-dimensional NMR, we determined the structure of the H3 stem-loop. Surprisingly, it forms a stable, homodimeric kissing complex through only two intermolecular G small middle dotC base pairs. Cross-strand interactions of the adenines adjacent to the intermolecular G small middle dotC base pairs, plus unusual strong electrostatic interactions around the base pairs, contribute to the unexpected stability. This structure shows how even stem-loops without self-complementary sequences can facilitate the intermolecular recognition between two identical RNAs, and thus initiate dimerization and encapsidation of retroviral RNAs.
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{{STRUCTURE_1f5u| PDB=1f5u | SCENE= }}
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A retroviral RNA kissing complex containing only two G.C base pairs.,Kim CH, Tinoco I Jr Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9396-401. PMID:10931958<ref>PMID:10931958</ref>
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===SOLUTION STRUCTURE OF THE KISSING DIMER OF H3 GACG STEM-LOOP IN THE 5'-END DIMERIZATION SIGNAL OF MOLONEY MURINE LEUKEMIA VIRUS GENOMIC RNA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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==About this Structure==
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<references/>
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[[1f5u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5U OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Kim, C H]]
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<ref group="xtra">PMID:010931958</ref><references group="xtra"/>
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[[Category: Tinoco, I]]
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[[Category: Kim, C H.]]
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[[Category: Tinoco, I.]]
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[[Category: Dimerization]]
[[Category: Dimerization]]
[[Category: Kissing dimer]]
[[Category: Kissing dimer]]

Revision as of 05:52, 22 December 2014

SOLUTION STRUCTURE OF THE KISSING DIMER OF H3 GACG STEM-LOOP IN THE 5'-END DIMERIZATION SIGNAL OF MOLONEY MURINE LEUKEMIA VIRUS GENOMIC RNA

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