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1evo

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[[Image:1evo.png|left|200px]]
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==NMR OBSERVATION OF A NOVEL C-TETRAD==
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<StructureSection load='1evo' size='340' side='right' caption='[[1evo]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1evo]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EVO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1evo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1evo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1evo RCSB], [http://www.ebi.ac.uk/pdbsum/1evo PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the NMR structure of the DNA sequence d-TGGGCGGT in Na(+) solutions at neutral pH, containing a repeat sequence from SV40 viral genome. The structure is a novel quadruplex incorporating the C-tetrad formed by symmetrical pairing of four Cs via NH(2)&bond;O(2) H-bonds in a plane. The C-tetrad has a wider cavity compared to G-tetrads and stacks well over the adjacent G4-tetrad, but poorly on the G6 tetrad. The quadruplex helix is largely underwound by 8-10 degrees compared to B-DNA except at the C5-G6 step. To our knowledge this is the first report of C-tetrad formation in DNA structures, and would be of significance from the point of view of both structural diversity and specific recognition.
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{{STRUCTURE_1evo| PDB=1evo | SCENE= }}
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NMR observation of a novel C-tetrad in the structure of the SV40 repeat sequence GGGCGG.,Patel PK, Bhavesh NS, Hosur RV Biochem Biophys Res Commun. 2000 Apr 21;270(3):967-71. PMID:10772934<ref>PMID:10772934</ref>
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===NMR OBSERVATION OF A NOVEL C-TETRAD===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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==About this Structure==
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<references/>
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[[1evo]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVO OCA].
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__TOC__
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</StructureSection>
[[Category: Bhavesh, N S.]]
[[Category: Bhavesh, N S.]]
[[Category: Hosur, R V.]]
[[Category: Hosur, R V.]]

Revision as of 11:23, 24 September 2014

NMR OBSERVATION OF A NOVEL C-TETRAD

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