2ymb

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[[Image:2ymb.png|left|200px]]
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==Structures of MITD1==
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<StructureSection load='2ymb' size='340' side='right' caption='[[2ymb]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ymb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YMB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a5x|4a5x]], [[4a5z|4a5z]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ymb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ymb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ymb RCSB], [http://www.ebi.ac.uk/pdbsum/2ymb PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MITD1_HUMAN MITD1_HUMAN]] Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.<ref>PMID:23015756</ref> <ref>PMID:23045692</ref> [[http://www.uniprot.org/uniprot/CHM1A_HUMAN CHM1A_HUMAN]] Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.<ref>PMID:8863740</ref> <ref>PMID:11559747</ref> <ref>PMID:11559748</ref> <ref>PMID:19129479</ref> <ref>PMID:23045692</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The endosomal sorting complexes required for transport (ESCRT) proteins have a critical function in abscission, the final separation of the daughter cells during cytokinesis. Here, we describe the structure and function of a previously uncharacterized ESCRT-III interacting protein, MIT-domain containing protein 1 (MITD1). Crystal structures of MITD1 reveal a dimer, with a microtubule-interacting and trafficking (MIT) domain at the N terminus and a unique, unanticipated phospholipase D-like (PLD) domain at the C terminus that binds membranes. We show that the MIT domain binds to a subset of ESCRT-III subunits and that this interaction mediates MITD1 recruitment to the midbody during cytokinesis. Depletion of MITD1 causes a distinct cytokinetic phenotype consistent with destabilization of the midbody and abscission failure. These results suggest a model whereby MITD1 coordinates the activity of ESCRT-III during abscission with earlier events in the final stages of cell division.
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{{STRUCTURE_2ymb| PDB=2ymb | SCENE= }}
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ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.,Hadders MA, Agromayor M, Obita T, Perisic O, Caballe A, Kloc M, Lamers MH, Williams RL, Martin-Serrano J Proc Natl Acad Sci U S A. 2012 Oct 8. PMID:23045692<ref>PMID:23045692</ref>
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===Structures of MITD1===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_23045692}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2ymb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMB OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Agromayor, M.]]
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[[Category: Agromayor, M]]
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[[Category: Caballe, A.]]
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[[Category: Caballe, A]]
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[[Category: Hadders, M A.]]
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[[Category: Hadders, M A]]
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[[Category: Kloc, M.]]
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[[Category: Kloc, M]]
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[[Category: Lamers, M H.]]
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[[Category: Lamers, M H]]
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[[Category: Martin-Serrano, J.]]
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[[Category: Martin-Serrano, J]]
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[[Category: Obita, T.]]
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[[Category: Obita, T]]
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[[Category: Perisic, O.]]
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[[Category: Perisic, O]]
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[[Category: Williams, R L.]]
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[[Category: Williams, R L]]
[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Pld]]
[[Category: Pld]]
[[Category: Protein transport]]
[[Category: Protein transport]]

Revision as of 19:08, 24 December 2014

Structures of MITD1

2ymb, resolution 3.40Å

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