4fwx

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[[Image:4fwx.png|left|200px]]
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==Aquoferric F33Y CuB myoglobin (F33Y L29H F43H sperm whale myoglobin)==
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<StructureSection load='4fwx' size='340' side='right' caption='[[4fwx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FWX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fwy|4fwy]], [[4fwz|4fwz]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9755 Physeter catodon])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fwx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fwx RCSB], [http://www.ebi.ac.uk/pdbsum/4fwx PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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No spare Tyr: Rational design of functional enzymes with a high number of turnovers is a challenge, especially those with a complex active site, such as respiratory oxidases. Introducing two His and one Tyr residues into myoglobin resulted in enzymes that reduce O(2) to H(2) O with more than 1000 turnovers (red line, see scheme) and minimal release of reactive oxygen species. The positioning of the Tyr residue is critical for activity.
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{{STRUCTURE_4fwx| PDB=4fwx | SCENE= }}
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A Designed Functional Metalloenzyme that Reduces O(2) to H(2) O with Over One Thousand Turnovers.,Miner KD, Mukherjee A, Gao YG, Null EL, Petrik ID, Zhao X, Yeung N, Robinson H, Lu Y Angew Chem Int Ed Engl. 2012 Jun 4;51(23):5589-92. doi: 10.1002/anie.201201981., Epub 2012 Apr 26. PMID:22539151<ref>PMID:22539151</ref>
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===Aquoferric F33Y CuB myoglobin (F33Y L29H F43H sperm whale myoglobin)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22539151}}
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==See Also==
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*[[Myoglobin|Myoglobin]]
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==About this Structure==
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== References ==
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[[4fwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWX OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022539151</ref><references group="xtra"/>
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[[Category: Physeter catodon]]
[[Category: Physeter catodon]]
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[[Category: Gao, Y G.]]
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[[Category: Gao, Y G]]
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[[Category: Lu, Y.]]
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[[Category: Lu, Y]]
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[[Category: Miner, K D.]]
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[[Category: Miner, K D]]
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[[Category: Petrik, I D.]]
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[[Category: Petrik, I D]]
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[[Category: Robinson, H.]]
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[[Category: Robinson, H]]
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[[Category: Stoner-Ma, D.]]
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[[Category: Stoner-Ma, D]]
[[Category: Globin]]
[[Category: Globin]]
[[Category: Oxidase]]
[[Category: Oxidase]]
[[Category: Transport protein]]
[[Category: Transport protein]]

Revision as of 01:12, 25 December 2014

Aquoferric F33Y CuB myoglobin (F33Y L29H F43H sperm whale myoglobin)

4fwx, resolution 1.90Å

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