1qbj

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[[Image:1qbj.jpg|left|200px]]<br /><applet load="1qbj" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1qbj.jpg|left|200px]]
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caption="1qbj, resolution 2.1&Aring;" />
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'''CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX'''<br />
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{{Structure
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|PDB= 1qbj |SIZE=350|CAPTION= <scene name='initialview01'>1qbj</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1QBJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBJ OCA].
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1QBJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBJ OCA].
==Reference==
==Reference==
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Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA., Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A, Science. 1999 Jun 11;284(5421):1841-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10364558 10364558]
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Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA., Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A, Science. 1999 Jun 11;284(5421):1841-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10364558 10364558]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein/z-dna complex]]
[[Category: protein/z-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:37:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:35:30 2008''

Revision as of 11:35, 20 March 2008

Image:1qbj.jpg


PDB ID 1qbj

Drag the structure with the mouse to rotate
, resolution 2.1Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX


Contents

Overview

The editing enzyme double-stranded RNA adenosine deaminase includes a DNA binding domain, Zalpha, which is specific for left-handed Z-DNA. The 2.1 angstrom crystal structure of Zalpha complexed to DNA reveals that the substrate is in the left-handed Z conformation. The contacts between Zalpha and Z-DNA are made primarily with the "zigzag" sugar-phosphate backbone, which provides a basis for the specificity for the Z conformation. A single base contact is observed to guanine in the syn conformation, characteristic of Z-DNA. Intriguingly, the helix-turn-helix motif, frequently used to recognize B-DNA, is used by Zalpha to contact Z-DNA.

Disease

Known diseases associated with this structure: Dyschromatosis symmetrica hereditaria OMIM:[601059]

About this Structure

1QBJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA., Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A, Science. 1999 Jun 11;284(5421):1841-5. PMID:10364558

Page seeded by OCA on Thu Mar 20 13:35:30 2008

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OCA

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