Transcription initiation factor
From Proteopedia
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<StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''> | <StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''> | ||
| - | '''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process. TFIID recognizes the promoter sequence on the DNA while TFIIB bridges between TFIID and RNA polymerase II. TFIIA is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA. | + | '''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process. '''TFIID''' recognizes the promoter sequence on the DNA while TFIIB bridges between TFIID and RNA polymerase II. '''TFIIA''' is one of several TFs which are required for transcription. '''TFIIA''' aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA. '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter. |
==3D structures of transcription initiation factors== | ==3D structures of transcription initiation factors== | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
===TFIIA=== | ===TFIIA=== | ||
| - | [[1ytf]] – | + | [[1ytf]], [[1nh2]], [[1rm1]] – yTFIIA + TBP + DNA – yeast<br /> |
| + | [[1nvp]] – hTFIIA + TATA-binding protein + DNA – human<br /> | ||
===TFIIB=== | ===TFIIB=== | ||
[[1pft]] – TFIIB N terminal – ''Pyrococcus furiosus'' – NMR<BR /> | [[1pft]] – TFIIB N terminal – ''Pyrococcus furiosus'' – NMR<BR /> | ||
| - | [[1tfb]] – hTFIIB | + | [[1tfb]] – hTFIIB - NMR<BR /> |
| + | [[1dl6]] - hTFIIB N terminal – NMR<br /> | ||
| + | [[1rly]] - hTFIIB Zn ribbon domain + Zn – NMR<br /> | ||
| + | [[1ro4]] - hTFIIB Zn ribbon domain – NMR<br /> | ||
[[1vol]], [[1c9b]] – hTFIIB + TBP + DNA<BR /> | [[1vol]], [[1c9b]] – hTFIIB + TBP + DNA<BR /> | ||
| + | [[3k1f]], [[3k7a]], [[4bbr]], [[4bbs]] – yTFIIB + RNA polymerase II<br /> | ||
[[1ais]], [[1d3u]] - TFIIB C terminal + TBP + DNA – ''Pyrococcus woesei'' | [[1ais]], [[1d3u]] - TFIIB C terminal + TBP + DNA – ''Pyrococcus woesei'' | ||
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[[1bh8]] – hTFIID<BR /> | [[1bh8]] – hTFIID<BR /> | ||
| + | [[1eqf]] – hTFIID subunit 1<br /> | ||
| + | [[3uv5]], [[3uv4]] – hTFIID subunit 1 bromodomain <br /> | ||
| + | [[3aad]] – hTFIID subunit 1 bromodomain + histone chaperone ASF1A<br /> | ||
[[1tba]] – TFIID – ''Drosophila melanogaster'' - NMR<BR /> | [[1tba]] – TFIID – ''Drosophila melanogaster'' - NMR<BR /> | ||
[[1bh9]] – hTFIID + PCMBS<BR /> | [[1bh9]] – hTFIID + PCMBS<BR /> | ||
| - | [[1qn3]], [[1qn4]], [[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]] – TFIID + DNA – ''Arabidopsis thaliana'' | + | [[1qn3]], [[1qn4]], [[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]], [[1qne]] – TFIID + DNA – ''Arabidopsis thaliana'' |
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| + | '''TFIIE''' | ||
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| + | [[1vd4]] - hTFIIB Zn finger domain – NMR<br /> | ||
| + | [[2rnq]] – hTFIIE C terminal - NMR<br /> | ||
| + | [[2rnr]] – hTFIIE C terminal + TFIIH PH domain- NMR<br /> | ||
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| + | '''TFIIF''' | ||
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| + | [[1f3u]] – hTFIIF<br /> | ||
| + | [[1nha]] – hTFIIF C terminal - NMR<br /> | ||
| + | [[1i27]] – hTFIIF C terminal (mutant)<br /> | ||
| + | [[1j2x]] – hTFIIF C terminal + RNA polymerase CTD phosphatase peptide<br /> | ||
| + | [[1onv]] – hTFIIF C terminal + serine phosphatase peptide - NMR<br /> | ||
| + | [[2k7l]] – hTFIIF C terminal + FCP1 peptide - NMR<br /> | ||
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Revision as of 10:09, 11 August 2013
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