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Trypanothione reductase
From Proteopedia
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==3D structures of trypanothione reductase== | ==3D structures of trypanothione reductase== | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[2tpr]], [[1tyt]], [[1fea]], [[1feb]], [[1fec]] – CfTTR – ''Crithidia fasciculate''<br /> | [[2tpr]], [[1tyt]], [[1fea]], [[1feb]], [[1fec]] – CfTTR – ''Crithidia fasciculate''<br /> | ||
| - | [[1aog]] – TcTTR – ''Trypanosoma cruzi''<br /> | + | [[1aog]], [[1nda]] – TcTTR – ''Trypanosoma cruzi''<br /> |
[[2jk6]] - LiTTR – ''Leishmania infantum''<br /> | [[2jk6]] - LiTTR – ''Leishmania infantum''<br /> | ||
[[2woi]] - TbTTR – ''Trypanosoma brucei'' | [[2woi]] - TbTTR – ''Trypanosoma brucei'' | ||
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[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /> | [[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /> | ||
[[2yau]] - LiTTR + NADPH + inhibitor<br /> | [[2yau]] - LiTTR + NADPH + inhibitor<br /> | ||
| - | [[2wow]] - TbTTR + NADPH + TPT<BR /> | + | [[2wow]] - TbTTR + NADPH + TPT<BR /> |
| + | [[4adw]] - LiTTR + NADPH + TPT<br /> | ||
| + | [[4apn]] - LiTTR + NADPH + inhibitor<br /> | ||
| + | |||
[[1typ]] – CfTTR + NADP + TPT<BR /> | [[1typ]] – CfTTR + NADP + TPT<BR /> | ||
Revision as of 11:22, 16 May 2013
Trypanothione reductase (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. TTR is found only in parasitic protozoa, hence its inhibitors are used as effective drugs against diseases caused by the parasites Trypanosoma and Leishmania.
3D structures of trypanothione reductase
Updated on 16-May-2013
2tpr, 1tyt, 1fea, 1feb, 1fec – CfTTR – Crithidia fasciculate
1aog, 1nda – TcTTR – Trypanosoma cruzi
2jk6 - LiTTR – Leishmania infantum
2woi - TbTTR – Trypanosoma brucei
TTR binary complex
1bzl - TcTTR + TPT
1gxf - TcTTR + inhibitor
2wba, 2wov - TbTTR + NADPH
2wp5, 2wp6, 2wpc, 2wpe, 2wpf - TbTTR + inhibitor
TTR ternary complex
2w0h, 2x50 - LiTTR + NADPH + metal ion
2yau - LiTTR + NADPH + inhibitor
2wow - TbTTR + NADPH + TPT
4adw - LiTTR + NADPH + TPT
4apn - LiTTR + NADPH + inhibitor
1typ – CfTTR + NADP + TPT
