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3w0t

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'''Unreleased structure'''
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{{STRUCTURE_3w0t| PDB=3w0t | SCENE= }}
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===Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor===
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The entry 3w0t is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref>
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Authors: Fukami, T.A., Irie, M., Matsuura, T.
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==About this Structure==
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[[3w0t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0T OCA].
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Description: Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Lactoylglutathione lyase]]
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[[Category: Fukami, T A.]]
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[[Category: Irie, M.]]
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[[Category: Matsuura, T.]]
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[[Category: Glyoxalase]]
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[[Category: Lyase-lyase inhibitor complex]]

Revision as of 07:35, 6 November 2013

Template:STRUCTURE 3w0t

Contents

Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor

Function

[LGUL_HUMAN] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.[1]

About this Structure

3w0t is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ de Hemptinne V, Rondas D, Toepoel M, Vancompernolle K. Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB. Mol Cell Biochem. 2009 May;325(1-2):169-78. doi: 10.1007/s11010-009-0031-7. Epub , 2009 Feb 6. PMID:19199007 doi:http://dx.doi.org/10.1007/s11010-009-0031-7

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OCA

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