1qfm

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[[Image:1qfm.jpg|left|200px]]<br /><applet load="1qfm" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1qfm.jpg|left|200px]]
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caption="1qfm, resolution 1.400&Aring;" />
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'''PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE'''<br />
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{{Structure
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|PDB= 1qfm |SIZE=350|CAPTION= <scene name='initialview01'>1qfm</scene>, resolution 1.400&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SGL:1-HYDROXY-1-THIO-GLYCEROL'>SGL</scene>, <scene name='pdbligand=SGM:MONOTHIOGLYCEROL'>SGM</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26]
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|GENE=
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}}
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'''PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1QFM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=SGL:'>SGL</scene>, <scene name='pdbligand=SGM:'>SGM</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFM OCA].
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1QFM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFM OCA].
==Reference==
==Reference==
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Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis., Fulop V, Bocskei Z, Polgar L, Cell. 1998 Jul 24;94(2):161-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9695945 9695945]
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Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis., Fulop V, Bocskei Z, Polgar L, Cell. 1998 Jul 24;94(2):161-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9695945 9695945]
[[Category: Prolyl oligopeptidase]]
[[Category: Prolyl oligopeptidase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: prolyl oligopeptidase]]
[[Category: prolyl oligopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:36:45 2008''

Revision as of 11:36, 20 March 2008

Image:1qfm.jpg


PDB ID 1qfm

Drag the structure with the mouse to rotate
, resolution 1.400Å
Ligands: , and
Activity: Prolyl oligopeptidase, with EC number 3.4.21.26
Coordinates: save as pdb, mmCIF, xml



PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE


Overview

Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here. The enzyme contains a peptidase domain with an alpha/beta hydrolase fold, and its catalytic triad (Ser554, His680, Asp641) is covered by the central tunnel of an unusual beta propeller. This domain makes prolyl oligopeptidase an oligopeptidase by excluding large structured peptides from the active site. In this way, the propeller protects larger peptides and proteins from proteolysis in the cytosol. The structure is also obtained with a transition state inhibitor, which may facilitate drug design to treat memory disorders.

About this Structure

1QFM is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis., Fulop V, Bocskei Z, Polgar L, Cell. 1998 Jul 24;94(2):161-70. PMID:9695945

Page seeded by OCA on Thu Mar 20 13:36:45 2008

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