1qft

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[[Image:1qft.gif|left|200px]]<br /><applet load="1qft" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1qft.gif|left|200px]]
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caption="1qft, resolution 1.25&Aring;" />
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'''HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS'''<br />
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{{Structure
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|PDB= 1qft |SIZE=350|CAPTION= <scene name='initialview01'>1qft</scene>, resolution 1.25&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1QFT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rhipicephalus_appendiculatus Rhipicephalus appendiculatus] with <scene name='pdbligand=HSM:'>HSM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFT OCA].
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1QFT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rhipicephalus_appendiculatus Rhipicephalus appendiculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFT OCA].
==Reference==
==Reference==
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Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure., Paesen GC, Adams PL, Harlos K, Nuttall PA, Stuart DI, Mol Cell. 1999 May;3(5):661-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10360182 10360182]
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Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure., Paesen GC, Adams PL, Harlos K, Nuttall PA, Stuart DI, Mol Cell. 1999 May;3(5):661-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10360182 10360182]
[[Category: Rhipicephalus appendiculatus]]
[[Category: Rhipicephalus appendiculatus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: lipocalin]]
[[Category: lipocalin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:39:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:36:52 2008''

Revision as of 11:36, 20 March 2008

Image:1qft.gif


PDB ID 1qft

Drag the structure with the mouse to rotate
, resolution 1.25Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS


Overview

High-affinity histamine-binding proteins (HBPs) were discovered in the saliva of Rhipicephalus appendiculatus ticks. Their ability to outcompete histamine receptors indicates that they suppress inflammation during blood feeding. The crystal structure of a histamine-bound HBP, determined at 1.25 A resolution, reveals a lipocalin fold novel in containing two binding sites for the same ligand. The sites are orthogonally arranged and highly rigid and form an internal surface of unusual polar character that complements the physicochemical properties of histamine. As soluble receptors of histamine, HBPs offer a new strategy for controlling histamine-based diseases.

About this Structure

1QFT is a Single protein structure of sequence from Rhipicephalus appendiculatus. Full crystallographic information is available from OCA.

Reference

Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure., Paesen GC, Adams PL, Harlos K, Nuttall PA, Stuart DI, Mol Cell. 1999 May;3(5):661-71. PMID:10360182

Page seeded by OCA on Thu Mar 20 13:36:52 2008

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