1qhv
From Proteopedia
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| - | [[Image:1qhv.jpg|left|200px]] | + | [[Image:1qhv.jpg|left|200px]] |
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| - | '''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD''' | + | {{Structure |
| + | |PDB= 1qhv |SIZE=350|CAPTION= <scene name='initialview01'>1qhv</scene>, resolution 1.51Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2]) | ||
| + | }} | ||
| + | |||
| + | '''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QHV is a [ | + | 1QHV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHV OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:[http:// | + | Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10502512 10502512] |
[[Category: Human adenovirus 2]] | [[Category: Human adenovirus 2]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: receptor binding]] | [[Category: receptor binding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:37:41 2008'' |
Revision as of 11:37, 20 March 2008
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| , resolution 1.51Å | |||||||
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| Ligands: | |||||||
| Gene: | LOCUS AD2H2 (Human adenovirus 2) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD
Overview
Adenovirus binds to its receptor via the head domain of its fiber protein. We have crystallized the adenovirus serotype 2 (subgroup C) receptor binding domain and solved the structure at 1.5 A resolution by the molecular replacement technique using the known adenovirus type 5 head structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic temperature factors for each atom. The overall structure of the serotype 2 head is very similar to its serotype 5 homologue, apart from differences in some of the flexible loops. All but subgroup B adenoviruses are believed to use the recently identified protein CAR (Coxsackievirus and adenovirus receptor) as receptor. By comparison of the two structures and sequence alignment of CAR binding and non-CAR binding serotype fiber heads, we discuss possible receptor binding sites and propose a receptor binding site in a crevice between two monomers on the side of the trimer. The structural basis of the extraordinary stability of the fiber head trimer is also discussed.
About this Structure
1QHV is a Single protein structure of sequence from Human adenovirus 2. Full crystallographic information is available from OCA.
Reference
Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:10502512
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