1qi7
From Proteopedia
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| - | [[Image:1qi7.gif|left|200px]] | + | [[Image:1qi7.gif|left|200px]] |
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| - | '''THE CRYSTAL STRUCTURE AT 2.0 A OF SAPORIN SO6, A RIBOSOME INACTIVATING PROTEIN FROM SAPONARIA OFFICINALIS''' | + | {{Structure |
| + | |PDB= 1qi7 |SIZE=350|CAPTION= <scene name='initialview01'>1qi7</scene>, resolution 2.0Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THE CRYSTAL STRUCTURE AT 2.0 A OF SAPORIN SO6, A RIBOSOME INACTIVATING PROTEIN FROM SAPONARIA OFFICINALIS''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QI7 is a [ | + | 1QI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saponaria_officinalis Saponaria officinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QI7 OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome., Savino C, Federici L, Ippoliti R, Lendaro E, Tsernoglou D, FEBS Lett. 2000 Mar 31;470(3):239-43. PMID:[http:// | + | The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome., Savino C, Federici L, Ippoliti R, Lendaro E, Tsernoglou D, FEBS Lett. 2000 Mar 31;470(3):239-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10745075 10745075] |
[[Category: Saponaria officinalis]] | [[Category: Saponaria officinalis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ribosome inactivating protein]] | [[Category: ribosome inactivating protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:37:51 2008'' |
Revision as of 11:37, 20 March 2008
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| , resolution 2.0Å | |||||||
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| Ligands: | |||||||
| Activity: | rRNA N-glycosylase, with EC number 3.2.2.22 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE CRYSTAL STRUCTURE AT 2.0 A OF SAPORIN SO6, A RIBOSOME INACTIVATING PROTEIN FROM SAPONARIA OFFICINALIS
Overview
The 2.0 A resolution crystal structure of the ribosome inactivating protein saporin (isoform 6) from seeds of Saponaria officinalis is presented. The fold typical of other plant toxins is conserved, despite some differences in the loop regions. The loop between strands beta7 and beta8 in the C-terminal region which spans over the active site cleft appears shorter in saporin, suggesting an easier access to the substrate. Furthermore we investigated the molecular interaction between saporin and the yeast ribosome by differential chemical modifications. A contact surface inside the C-terminal region of saporin has been identified. Structural comparison between saporin and other ribosome inactivating proteins reveals that this region is conserved and represents a peculiar motif involved in ribosome recognition.
About this Structure
1QI7 is a Single protein structure of sequence from Saponaria officinalis. Full crystallographic information is available from OCA.
Reference
The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome., Savino C, Federici L, Ippoliti R, Lendaro E, Tsernoglou D, FEBS Lett. 2000 Mar 31;470(3):239-43. PMID:10745075
Page seeded by OCA on Thu Mar 20 13:37:51 2008
