1qnd
From Proteopedia
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| - | [[Image:1qnd.gif|left|200px]] | + | [[Image:1qnd.gif|left|200px]] |
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| - | '''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES''' | + | {{Structure |
| + | |PDB= 1qnd |SIZE=350|CAPTION= <scene name='initialview01'>1qnd</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QND is a [ | + | 1QND is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QND OCA]. |
==Reference== | ==Reference== | ||
| - | NMR structure of the sterol carrier protein-2: implications for the biological role., Garcia FL, Szyperski T, Dyer JH, Choinowski T, Seedorf U, Hauser H, Wuthrich K, J Mol Biol. 2000 Jan 21;295(3):595-603. PMID:[http:// | + | NMR structure of the sterol carrier protein-2: implications for the biological role., Garcia FL, Szyperski T, Dyer JH, Choinowski T, Seedorf U, Hauser H, Wuthrich K, J Mol Biol. 2000 Jan 21;295(3):595-603. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10623549 10623549] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Wuthrich, K.]] | [[Category: Wuthrich, K.]] | ||
[[Category: lipid binding]] | [[Category: lipid binding]] | ||
| - | [[Category: nitroxide spin | + | [[Category: nitroxide spin label]] |
| - | [[Category: protein | + | [[Category: protein dynamic]] |
[[Category: protein structure]] | [[Category: protein structure]] | ||
[[Category: sterol carrier protein 2]] | [[Category: sterol carrier protein 2]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:40:02 2008'' |
Revision as of 11:40, 20 March 2008
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STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES
Overview
The determination of the NMR structure of the sterol carrier protein-2 (SCP2), analysis of backbone (15)N spin relaxation parameters and NMR studies of nitroxide spin-labeled substrate binding are presented as a new basis for investigations of the mode of action of SCP2. The SCP2 fold is formed by a five-stranded beta-sheet and four alpha-helices. Fatty acid binding to a hydrophobic surface area formed by amino acid residues of the first and third helices, and the beta-sheet, which are all located in the polypeptide segment 8-102, was identified with the use of the spin-labeled substrate 16-doxylstearic acid. In the free protein, the lipid-binding site is covered by the C-terminal segment 105-123, suggesting that this polypeptide segment, which carries the peroxisomal targeting signal (PTS1), might be involved in the regulation of ligand binding.
About this Structure
1QND is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
NMR structure of the sterol carrier protein-2: implications for the biological role., Garcia FL, Szyperski T, Dyer JH, Choinowski T, Seedorf U, Hauser H, Wuthrich K, J Mol Biol. 2000 Jan 21;295(3):595-603. PMID:10623549
Page seeded by OCA on Thu Mar 20 13:40:02 2008
