1h1d
From Proteopedia
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| - | [[Image:1h1d.png|left|200px]] | ||
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{{STRUCTURE_1h1d| PDB=1h1d | SCENE= }} | {{STRUCTURE_1h1d| PDB=1h1d | SCENE= }} | ||
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===CATECHOL O-METHYLTRANSFERASE=== | ===CATECHOL O-METHYLTRANSFERASE=== | ||
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{{ABSTRACT_PUBMED_12237326}} | {{ABSTRACT_PUBMED_12237326}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1h1d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[1h1d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H1D OCA]. |
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| + | ==See Also== | ||
| + | *[[Catechol O-methyltransferase|Catechol O-methyltransferase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:012237326</ref><references group="xtra"/> | + | <ref group="xtra">PMID:012237326</ref><references group="xtra"/><references/> |
| + | [[Category: Buffalo rat]] | ||
[[Category: Catechol O-methyltransferase]] | [[Category: Catechol O-methyltransferase]] | ||
| - | [[Category: Rattus norvegicus]] | ||
[[Category: Archer, M.]] | [[Category: Archer, M.]] | ||
[[Category: Bonifacio, M J.]] | [[Category: Bonifacio, M J.]] | ||
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[[Category: Matias, P M.]] | [[Category: Matias, P M.]] | ||
[[Category: Rodrigues, M L.]] | [[Category: Rodrigues, M L.]] | ||
| - | [[Category: Soares-Da- | + | [[Category: Soares-Da-silva, P.]] |
[[Category: Methyltransferase]] | [[Category: Methyltransferase]] | ||
[[Category: Neurotransmitter degradation]] | [[Category: Neurotransmitter degradation]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 14:17, 19 February 2014
Contents |
CATECHOL O-METHYLTRANSFERASE
Template:ABSTRACT PUBMED 12237326
Function
[COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
About this Structure
1h1d is a 1 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.
See Also
Reference
- Bonifacio MJ, Archer M, Rodrigues ML, Matias PM, Learmonth DA, Carrondo MA, Soares-Da-Silva P. Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application. Mol Pharmacol. 2002 Oct;62(4):795-805. PMID:12237326
