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1qo3
From Proteopedia
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| - | [[Image:1qo3.gif|left|200px]] | + | [[Image:1qo3.gif|left|200px]] |
| - | + | ||
| - | '''COMPLEX BETWEEN NK CELL RECEPTOR LY49A AND ITS MHC CLASS I LIGAND H-2DD''' | + | {{Structure |
| + | |PDB= 1qo3 |SIZE=350|CAPTION= <scene name='initialview01'>1qo3</scene>, resolution 2.30Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= H-2D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''COMPLEX BETWEEN NK CELL RECEPTOR LY49A AND ITS MHC CLASS I LIGAND H-2DD''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QO3 is a [ | + | 1QO3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QO3 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand., Tormo J, Natarajan K, Margulies DH, Mariuzza RA, Nature. 1999 Dec 9;402(6762):623-31. PMID:[http:// | + | Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand., Tormo J, Natarajan K, Margulies DH, Mariuzza RA, Nature. 1999 Dec 9;402(6762):623-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10604468 10604468] |
[[Category: Human immunodeficiency virus]] | [[Category: Human immunodeficiency virus]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: nk cell]] | [[Category: nk cell]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:40:26 2008'' |
Revision as of 11:40, 20 March 2008
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| , resolution 2.30Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | H-2D (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
COMPLEX BETWEEN NK CELL RECEPTOR LY49A AND ITS MHC CLASS I LIGAND H-2DD
Overview
Natural killer (NK) cell function is regulated by NK receptors that interact with MHC class I (MHC-I) molecules on target cells. The murine NK receptor Ly49A inhibits NK cell activity by interacting with H-2D(d) through its C-type-lectin-like NK receptor domain. Here we report the crystal structure of the complex between the Ly49A NK receptor domain and unglycosylated H-2D(d). The Ly49A dimer interacts extensively with two H-2D(d) molecules at distinct sites. At one interface, a single Ly49A subunit contacts one side of the MHC-I peptide-binding platform, presenting an open cavity towards the conserved glycosylation site on the H-2D(d) alpha2 domain. At a second, larger interface, the Ly49A dimer binds in a region overlapping the CD8-binding site. The smaller interface probably represents the interaction between Ly49A on the NK cell and MHC-I on the target cell, whereas the larger one suggests an interaction between Ly49A and MHC-I on the NK cell itself. Both Ly49A binding sites on MHC-I are spatially distinct from that of the T-cell receptor.
About this Structure
1QO3 is a Protein complex structure of sequences from Human immunodeficiency virus and Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand., Tormo J, Natarajan K, Margulies DH, Mariuzza RA, Nature. 1999 Dec 9;402(6762):623-31. PMID:10604468
Page seeded by OCA on Thu Mar 20 13:40:26 2008
