1qrq

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[[Image:1qrq.gif|left|200px]]<br /><applet load="1qrq" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1qrq.gif|left|200px]]
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caption="1qrq, resolution 2.80&Aring;" />
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'''STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT'''<br />
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{{Structure
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|PDB= 1qrq |SIZE=350|CAPTION= <scene name='initialview01'>1qrq</scene>, resolution 2.80&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE'>NDP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1QRQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=NDP:'>NDP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRQ OCA].
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1QRQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRQ OCA].
==Reference==
==Reference==
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Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10399921 10399921]
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Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10399921 10399921]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: voltage-dependent potassium channel]]
[[Category: voltage-dependent potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:43:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:41:52 2008''

Revision as of 11:41, 20 March 2008

Image:1qrq.gif


PDB ID 1qrq

Drag the structure with the mouse to rotate
, resolution 2.80Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT


Overview

The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the beta subunit. One function of beta subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian beta subunits by X-ray crystallography at 2.8 A resolution. Like the integral membrane component of K+ channels, beta subunits form a four-fold symmetric structure. Each subunit is an oxidoreductase enzyme complete with a nicotinamide co-factor in its active site. Several structural features of the enzyme active site, including its location with respect to the four-fold axis, imply that it may interact directly or indirectly with the K+ channel's voltage sensor. This structure suggests a mechanism for coupling membrane electrical excitability directly to chemistry of the cell.

About this Structure

1QRQ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:10399921

Page seeded by OCA on Thu Mar 20 13:41:52 2008

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