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1gz0

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[[Image:1gz0.png|left|200px]]
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==23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB==
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<StructureSection load='1gz0' size='340' side='right' caption='[[1gz0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gz0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GZ0 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gz0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gz0 PDBsum], [http://www.topsan.org/Proteins/BSGI/1gz0 TOPSAN]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/1gz0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In Escherichia coli, RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. The crystal structure of this 2'O-methyltransferase has been determined at 2.5 A resolution. RlmB consists of an N-terminal domain connected by a flexible extended linker to a catalytic C-terminal domain and forms a dimer in solution. The C-terminal domain displays a divergent methyltransferase fold with a unique knotted region, and lacks the classic AdoMet binding site features. The N-terminal domain is similar to ribosomal proteins L7 and L30, suggesting a role in 23S rRNA recognition. The conserved residues in this novel family of 2'O-methyltransferases cluster in the knotted region, suggesting the location of the catalytic and AdoMet binding sites.
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{{STRUCTURE_1gz0| PDB=1gz0 | SCENE= }}
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The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot.,Michel G, Sauve V, Larocque R, Li Y, Matte A, Cygler M Structure. 2002 Oct;10(10):1303-15. PMID:12377117<ref>PMID:12377117</ref>
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===23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12377117}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1gz0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZ0 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012377117</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Cygler, M.]]
[[Category: Cygler, M.]]

Revision as of 13:30, 28 September 2014

23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB

1gz0, resolution 2.50Å

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