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1gtq
From Proteopedia
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| - | [[Image:1gtq.png|left|200px]] | ||
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{{STRUCTURE_1gtq| PDB=1gtq | SCENE= }} | {{STRUCTURE_1gtq| PDB=1gtq | SCENE= }} | ||
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===6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE=== | ===6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE=== | ||
| + | {{ABSTRACT_PUBMED_8137809}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT]] Note=Deficiency leads to phenylketonuria. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT]] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:008137809</ref><references group="xtra"/> | + | <ref group="xtra">PMID:008137809</ref><references group="xtra"/><references/> |
[[Category: 6-pyruvoyltetrahydropterin synthase]] | [[Category: 6-pyruvoyltetrahydropterin synthase]] | ||
[[Category: Rattus rattus]] | [[Category: Rattus rattus]] | ||
Revision as of 04:57, 25 March 2013
Contents |
6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE
Template:ABSTRACT PUBMED 8137809
Disease
[PTPS_RAT] Note=Deficiency leads to phenylketonuria.
Function
[PTPS_RAT] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
About this Structure
1gtq is a 2 chain structure with sequence from Rattus rattus. Full crystallographic information is available from OCA.
Reference
- Nar H, Huber R, Heizmann CW, Thony B, Burgisser D. Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis. EMBO J. 1994 Mar 15;13(6):1255-62. PMID:8137809
