1g6u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1g6u" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:1g6u.png|left|200px]]
+
==CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER==
 +
<StructureSection load='1g6u' size='340' side='right' caption='[[1g6u]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1g6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G6U FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene><br>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g6u RCSB], [http://www.ebi.ac.uk/pdbsum/1g6u PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Three-dimensional (3D) domain-swapped proteins are intermolecularly folded analogs of monomeric proteins; both are stabilized by the identical interactions, but the individual domains interact intramolecularly in monomeric proteins, whereas they form intermolecular interactions in 3D domain-swapped structures. The structures and conditions of formation of several domain-swapped dimers and trimers are known, but the formation of higher order 3D domain-swapped oligomers has been less thoroughly studied. Here we contrast the structural consequences of domain swapping from two designed three-helix bundles: one with an up-down-up topology, and the other with an up-down-down topology. The up-down-up topology gives rise to a domain-swapped dimer whose structure has been determined to 1.5 A resolution by x-ray crystallography. In contrast, the domain-swapped protein with an up-down-down topology forms fibrils as shown by electron microscopy and dynamic light scattering. This demonstrates that design principles can predict the oligomeric state of 3D domain-swapped molecules, which should aid in the design of domain-swapped proteins and biomaterials.
-
{{STRUCTURE_1g6u| PDB=1g6u | SCENE= }}
+
Design of three-dimensional domain-swapped dimers and fibrous oligomers.,Ogihara NL, Ghirlanda G, Bryson JW, Gingery M, DeGrado WF, Eisenberg D Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1404-9. PMID:11171963<ref>PMID:11171963</ref>
-
===CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_11171963}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1g6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6U OCA].
+
</StructureSection>
[[Category: Bryson, J W.]]
[[Category: Bryson, J W.]]
[[Category: DeGrado, W F.]]
[[Category: DeGrado, W F.]]

Revision as of 14:31, 28 September 2014

CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER

1g6u, resolution 1.48Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g6u"
Views
Personal tools
Navigation
Toolbox