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1g6u

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[[Image:1g6u.png|left|200px]]
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==CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER==
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<StructureSection load='1g6u' size='340' side='right' caption='[[1g6u]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1g6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G6U FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g6u RCSB], [http://www.ebi.ac.uk/pdbsum/1g6u PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Three-dimensional (3D) domain-swapped proteins are intermolecularly folded analogs of monomeric proteins; both are stabilized by the identical interactions, but the individual domains interact intramolecularly in monomeric proteins, whereas they form intermolecular interactions in 3D domain-swapped structures. The structures and conditions of formation of several domain-swapped dimers and trimers are known, but the formation of higher order 3D domain-swapped oligomers has been less thoroughly studied. Here we contrast the structural consequences of domain swapping from two designed three-helix bundles: one with an up-down-up topology, and the other with an up-down-down topology. The up-down-up topology gives rise to a domain-swapped dimer whose structure has been determined to 1.5 A resolution by x-ray crystallography. In contrast, the domain-swapped protein with an up-down-down topology forms fibrils as shown by electron microscopy and dynamic light scattering. This demonstrates that design principles can predict the oligomeric state of 3D domain-swapped molecules, which should aid in the design of domain-swapped proteins and biomaterials.
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{{STRUCTURE_1g6u| PDB=1g6u | SCENE= }}
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Design of three-dimensional domain-swapped dimers and fibrous oligomers.,Ogihara NL, Ghirlanda G, Bryson JW, Gingery M, DeGrado WF, Eisenberg D Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1404-9. PMID:11171963<ref>PMID:11171963</ref>
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===CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11171963}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1g6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6U OCA].
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</StructureSection>
[[Category: Bryson, J W.]]
[[Category: Bryson, J W.]]
[[Category: DeGrado, W F.]]
[[Category: DeGrado, W F.]]

Revision as of 14:31, 28 September 2014

CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER

1g6u, resolution 1.48Å

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