1hy9

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[[Image:1hy9.png|left|200px]]
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==COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT==
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<StructureSection load='1hy9' size='340' side='right' caption='[[1hy9]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hy9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HY9 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hy9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hy9 RCSB], [http://www.ebi.ac.uk/pdbsum/1hy9 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/1hy9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. The C-terminal part containing the three disulfide bridges CART(48-89) is the biologically active part of the molecule affecting food intake. The solution structure of the active part of CART has a fold equivalent to other functionally distinct small proteins. CART consists mainly of turns and loops spanned by a compact framework composed by a few small stretches of antiparallel beta-sheet common to cystine knots.
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{{STRUCTURE_1hy9| PDB=1hy9 | SCENE= }}
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Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold.,Ludvigsen S, Thim L, Blom AM, Wulff BS Biochemistry. 2001 Aug 7;40(31):9082-8. PMID:11478874<ref>PMID:11478874</ref>
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===COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11478874}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1hy9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY9 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:011478874</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Blom, A M.]]
[[Category: Blom, A M.]]

Revision as of 10:35, 28 September 2014

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT

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