Sandbox Reserved 651

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== Introduction ==
== Introduction ==
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The retrovirus human immunodeficiency virus (HIV) is a subsequent progression to acquired immune deficiency syndrome (AIDS). This disease is a continuous worldwide epidemic. The protein HIV-1 reverse transcriptase is one of the key players in the mechanism of infections by this retrovirus. The protein HIV-I reverse transcriptase is the enzyme that’s main responsibility is to copy a single-stranded viral RNA genome into a double stranded DNA.<ref>1<re/> In turn the newly developed DNA can then be incorporated into the host cell genome. The HIV-1 reverse transcriptase enzyme has two domains within its structure. The two domains are a DNA polymerase domain and ribonuclease H (also called RNase H) domain. The role of the DNA polymerase is to copy either RNA or DNA template strands. The purpose of the ribonuclease H is to cleave the RNA duplex after the DNA synthesis has occurred so that the newly created DNA can generate a second strand.
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The retrovirus human immunodeficiency virus (HIV) is a subsequent progression to acquired immune deficiency syndrome (AIDS). This disease is a continuous worldwide epidemic. The protein HIV-1 reverse transcriptase is one of the key players in the mechanism of infections by this retrovirus. The protein HIV-I reverse transcriptase is the enzyme that’s main responsibility is to copy a single-stranded viral RNA genome into a double stranded DNA.<ref>1<ref/> In turn the newly developed DNA can then be incorporated into the host cell genome. The HIV-1 reverse transcriptase enzyme has two domains within its structure. The two domains are a DNA polymerase domain and ribonuclease H (also called RNase H) domain. The role of the DNA polymerase is to copy either RNA or DNA template strands. The purpose of the ribonuclease H is to cleave the RNA duplex after the DNA synthesis has occurred so that the newly created DNA can generate a second strand.<ref>2<ref/>
== Structure ==
== Structure ==
<Structure load='1FK9' size='500' frame='true' align='right' caption='HIV-1 RT in complex with efavirenz' scene='Insert optional scene name here' />
<Structure load='1FK9' size='500' frame='true' align='right' caption='HIV-1 RT in complex with efavirenz' scene='Insert optional scene name here' />

Revision as of 21:07, 26 November 2012

This Sandbox is Reserved from 30/08/2012, through 01/02/2013 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 636 through Sandbox Reserved 685.
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Human Immunodeficiency Virus-1 Reverse Transcriptase

Introduction

The retrovirus human immunodeficiency virus (HIV) is a subsequent progression to acquired immune deficiency syndrome (AIDS). This disease is a continuous worldwide epidemic. The protein HIV-1 reverse transcriptase is one of the key players in the mechanism of infections by this retrovirus. The protein HIV-I reverse transcriptase is the enzyme that’s main responsibility is to copy a single-stranded viral RNA genome into a double stranded DNA.[1]

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