User:Sruti Aiyaswamy/Sandbox 1
From Proteopedia
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==Structure of MR1-antigen Complex== | ==Structure of MR1-antigen Complex== | ||
<StructureSection load='4GUP' size='450' align='right' caption='Structure of MR1 in complex with b2m and 6-formyl' scene=''> | <StructureSection load='4GUP' size='450' align='right' caption='Structure of MR1 in complex with b2m and 6-formyl' scene=''> | ||
| - | Where does this lead? | + | Where does this lead? <scene name='User:Sruti_Aiyaswamy/Sandbox_1/Alpha_and_beta_chains/1'>TextToBeDisplayed</scene> |
</StructureSection> | </StructureSection> | ||
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==Biological Significance== | ==Biological Significance== | ||
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==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 08:54, 27 November 2012
Contents |
Introduction
The MHC class I-like molecule, MR1, is an antigen presenting protein that specifically activates mucosal-associated invariant T (MAIT) cells.[1] It has been found that microbial vitamin B metabolites serve as MR1 ligands that activate the MAIT cells.
MR1 is MHC Class I Related
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Finally relate how MHC structure/function is similar to MR1. Explain chains, b2m, folding.
Structure of MR1-antigen Complex
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MR1-restricted MAIT Activation
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Biological Significance
References
- ↑ Ochs HD, Oukka M, Torgerson TR. TH17 cells and regulatory T cells in primary immunodeficiency diseases. J Allergy Clin Immunol. 2009 May;123(5):977-83; quiz 984-5. PMID:19410687 doi:10.1016/j.jaci.2009.03.030
