1qys
From Proteopedia
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| - | [[Image:1qys.gif|left|200px]] | + | [[Image:1qys.gif|left|200px]] |
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| - | '''Crystal structure of Top7: A computationally designed protein with a novel fold''' | + | {{Structure |
| + | |PDB= 1qys |SIZE=350|CAPTION= <scene name='initialview01'>1qys</scene>, resolution 2.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Crystal structure of Top7: A computationally designed protein with a novel fold''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QYS is a [ | + | 1QYS is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Computationally_designed_sequence Computationally designed sequence]. The following page contains interesting information on the relation of 1QYS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYS OCA]. |
==Reference== | ==Reference== | ||
| - | Design of a novel globular protein fold with atomic-level accuracy., Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, Science. 2003 Nov 21;302(5649):1364-8. PMID:[http:// | + | Design of a novel globular protein fold with atomic-level accuracy., Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, Science. 2003 Nov 21;302(5649):1364-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14631033 14631033] |
[[Category: Computationally designed sequence]] | [[Category: Computationally designed sequence]] | ||
[[Category: Designer Proteins]] | [[Category: Designer Proteins]] | ||
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[[Category: novel fold]] | [[Category: novel fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:44:31 2008'' |
Revision as of 11:44, 20 March 2008
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Crystal structure of Top7: A computationally designed protein with a novel fold
Overview
A major challenge of computational protein design is the creation of novel proteins with arbitrarily chosen three-dimensional structures. Here, we used a general computational strategy that iterates between sequence design and structure prediction to design a 93-residue alpha/beta protein called Top7 with a novel sequence and topology. Top7 was found experimentally to be folded and extremely stable, and the x-ray crystal structure of Top7 is similar (root mean square deviation equals 1.2 angstroms) to the design model. The ability to design a new protein fold makes possible the exploration of the large regions of the protein universe not yet observed in nature.
About this Structure
1QYS is a Protein complex structure of sequences from Computationally designed sequence. The following page contains interesting information on the relation of 1QYS with [Designer Proteins]. Full crystallographic information is available from OCA.
Reference
Design of a novel globular protein fold with atomic-level accuracy., Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, Science. 2003 Nov 21;302(5649):1364-8. PMID:14631033
Page seeded by OCA on Thu Mar 20 13:44:31 2008
