1qzt

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[[Image:1qzt.gif|left|200px]]<br /><applet load="1qzt" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1qzt.gif|left|200px]]
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caption="1qzt, resolution 2.70&Aring;" />
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'''Phosphotransacetylase from Methanosarcina thermophila'''<br />
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{{Structure
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|PDB= 1qzt |SIZE=350|CAPTION= <scene name='initialview01'>1qzt</scene>, resolution 2.70&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphate_acetyltransferase Phosphate acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.8 2.3.1.8]
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|GENE= PTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2210 Methanosarcina thermophila])
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}}
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'''Phosphotransacetylase from Methanosarcina thermophila'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1QZT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_thermophila Methanosarcina thermophila] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphate_acetyltransferase Phosphate acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.8 2.3.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZT OCA].
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1QZT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_thermophila Methanosarcina thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZT OCA].
==Reference==
==Reference==
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Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila., Iyer PP, Lawrence SH, Luther KB, Rajashankar KR, Yennawar HP, Ferry JG, Schindelin H, Structure. 2004 Apr;12(4):559-67. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15062079 15062079]
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Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila., Iyer PP, Lawrence SH, Luther KB, Rajashankar KR, Yennawar HP, Ferry JG, Schindelin H, Structure. 2004 Apr;12(4):559-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15062079 15062079]
[[Category: Methanosarcina thermophila]]
[[Category: Methanosarcina thermophila]]
[[Category: Phosphate acetyltransferase]]
[[Category: Phosphate acetyltransferase]]
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[[Category: phosphotransacetylase (pta)]]
[[Category: phosphotransacetylase (pta)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:45:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:44:53 2008''

Revision as of 11:44, 20 March 2008

Image:1qzt.gif


PDB ID 1qzt

Drag the structure with the mouse to rotate
, resolution 2.70Å
Ligands:
Gene: PTA (Methanosarcina thermophila)
Activity: Phosphate acetyltransferase, with EC number 2.3.1.8
Coordinates: save as pdb, mmCIF, xml



Phosphotransacetylase from Methanosarcina thermophila


Overview

Phosphotransacetylase (Pta) [EC 2.3.1.8] is ubiquitous in the carbon assimilation and energy-yielding pathways in anaerobic prokaryotes where it catalyzes the reversible transfer of the acetyl group from acetyl phosphate to CoA forming acetyl CoA and inorganic phosphate. The crystal structure of Pta from the methane-producing archaeon Methanosarcina thermophila, representing the first crystal structure of any Pta, was determined by multiwavelength anomalous diffraction at 2.7 A resolution. In solution and in the crystal, the enzyme forms a homodimer. Each monomer consists of two alpha/beta domains with a cleft along the domain boundary, which presumably contains the substrate binding sites. Comparison of the four monomers present in the asymmetric unit indicates substantial variations in the relative orientation of the two domains and the structure of the putative active site cleft. A search for structural homologs revealed the NADP(+)-dependent isocitrate and isopropylmalate dehydrogenases as the only homologs with a similar two-domain architecture.

About this Structure

1QZT is a Single protein structure of sequence from Methanosarcina thermophila. Full crystallographic information is available from OCA.

Reference

Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila., Iyer PP, Lawrence SH, Luther KB, Rajashankar KR, Yennawar HP, Ferry JG, Schindelin H, Structure. 2004 Apr;12(4):559-67. PMID:15062079

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