1r02
From Proteopedia
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| - | [[Image:1r02.gif|left|200px]] | + | [[Image:1r02.gif|left|200px]] |
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| - | '''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness''' | + | {{Structure |
| + | |PDB= 1r02 |SIZE=350|CAPTION= <scene name='initialview01'>1r02</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1R02 is a [ | + | 1R02 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:[http:// | + | Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15479620 15479620] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hong, E.]] | [[Category: Hong, E.]] | ||
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[[Category: turn]] | [[Category: turn]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:45:02 2008'' |
Revision as of 11:45, 20 March 2008
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Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness
Contents |
Overview
Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are important hypothalamic neuro-peptides, which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined the solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with the hydrophobic residues disposed to on one side of helix, and hydrophilic residues to the other. A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B. With previous mutagenic studies, the derived structure of orexin-A provides us with a structure-functional view for novel drug design.
Disease
Known diseases associated with this structure: Narcolepsy OMIM:[602358], Porphyria variegata OMIM:[600923]
About this Structure
1R02 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:15479620
Page seeded by OCA on Thu Mar 20 13:45:02 2008
Categories: Single protein | Hong, E. | Kim, H Y. | Kim, J I. | Lee, W. | Helix-loop-helix | Turn
