1r1n
From Proteopedia
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| - | [[Image:1r1n.gif|left|200px]] | + | [[Image:1r1n.gif|left|200px]] |
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| - | '''Tri-nuclear oxo-iron clusters in the ferric binding protein from N. gonorrhoeae''' | + | {{Structure |
| + | |PDB= 1r1n |SIZE=350|CAPTION= <scene name='initialview01'>1r1n</scene>, resolution 1.74Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CNB:OXO-IRON+CLUSTER+1'>CNB</scene>, <scene name='pdbligand=CN1:OXO-IRON+CLUSTER+2'>CN1</scene> and <scene name='pdbligand=CNF:OXO-IRON CLUSTER 3'>CNF</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Tri-nuclear oxo-iron clusters in the ferric binding protein from N. gonorrhoeae''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1R1N is a [ | + | 1R1N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1N OCA]. |
==Reference== | ==Reference== | ||
| - | Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif., Zhu H, Alexeev D, Hunter DJ, Campopiano DJ, Sadler PJ, Biochem J. 2003 Nov 15;376(Pt 1):35-41. PMID:[http:// | + | Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif., Zhu H, Alexeev D, Hunter DJ, Campopiano DJ, Sadler PJ, Biochem J. 2003 Nov 15;376(Pt 1):35-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/13129433 13129433] |
[[Category: Neisseria gonorrhoeae]] | [[Category: Neisseria gonorrhoeae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: iron binding protein]] | [[Category: iron binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:45:37 2008'' |
Revision as of 11:45, 20 March 2008
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| , resolution 1.74Å | |||||||
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| Ligands: | , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Tri-nuclear oxo-iron clusters in the ferric binding protein from N. gonorrhoeae
Overview
We report a set of three 1.8-1.9 A resolution X-ray crystal structures of Neisseria gonorrhoeae Fbp (ferric-ion binding protein): (i) open-cleft apo-Fbp containing bound phosphate, (ii) open-cleft mono-Fe Fbp capped by nitrilotriacetate, and (iii) open-cleft trinuclear oxo-iron Fbp, the first structure of an iron-cluster adduct of a transferrin. The nine independent molecules in the unit cells provide 'snapshots' of the versatile dynamic structural roles of the conserved dityrosyl iron-binding motif (Tyr195-Tyr196) which control the capture and, possibly, processing of iron. These findings have implications for understanding bacterial iron acquisition and dissimilation, and organic/mineral interfaces.
About this Structure
1R1N is a Single protein structure of sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA.
Reference
Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif., Zhu H, Alexeev D, Hunter DJ, Campopiano DJ, Sadler PJ, Biochem J. 2003 Nov 15;376(Pt 1):35-41. PMID:13129433
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