1iie
From Proteopedia
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{{STRUCTURE_1iie| PDB=1iie | SCENE= }} | {{STRUCTURE_1iie| PDB=1iie | SCENE= }} | ||
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===HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN=== | ===HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN=== | ||
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{{ABSTRACT_PUBMED_9843486}} | {{ABSTRACT_PUBMED_9843486}} | ||
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| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.<ref>PMID:12661006</ref> | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. | ||
==About this Structure== | ==About this Structure== | ||
[[1iie]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. | [[1iie]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Jasanoff, A.]] | [[Category: Jasanoff, A.]] | ||
Revision as of 20:26, 24 March 2013
Contents |
HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN
Template:ABSTRACT PUBMED 9843486
Disease
[HG2A_HUMAN] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.[1]
Function
[HG2A_HUMAN] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
About this Structure
1iie is a 3 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- ↑ Charest A, Lane K, McMahon K, Park J, Preisinger E, Conroy H, Housman D. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer. 2003 May;37(1):58-71. PMID:12661006 doi:10.1002/gcc.10207
