1rau
From Proteopedia
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| - | [[Image:1rau.gif|left|200px]] | + | [[Image:1rau.gif|left|200px]] |
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| - | '''SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES''' | + | {{Structure |
| + | |PDB= 1rau |SIZE=350|CAPTION= <scene name='initialview01'>1rau</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RAU is a [ | + | 1RAU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RAU OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures., Cheong C, Moore PB, Biochemistry. 1992 Sep 15;31(36):8406-14. PMID:[http:// | + | Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures., Cheong C, Moore PB, Biochemistry. 1992 Sep 15;31(36):8406-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1382577 1382577] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Cheong, C.]] | [[Category: Cheong, C.]] | ||
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[[Category: tetraplex]] | [[Category: tetraplex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:49:05 2008'' |
Revision as of 11:49, 20 March 2008
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SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES
Overview
A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware.
About this Structure
1RAU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures., Cheong C, Moore PB, Biochemistry. 1992 Sep 15;31(36):8406-14. PMID:1382577
Page seeded by OCA on Thu Mar 20 13:49:05 2008
Categories: Protein complex | Cheong, C. | Moore, P B. | Nmr | Rna | Tetraplex
