SandboxPKA
From Proteopedia
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Morado dominio SH3 | Morado dominio SH3 | ||
Rojo dominio SH2 | Rojo dominio SH2 | ||
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</StructureSection> | </StructureSection> | ||
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| + | <StructureSection load='3DY7' size='350' side='right' caption='ATP binding domain'> | ||
Aquí se sigue | Aquí se sigue | ||
| - | </3DY7> | ||
Revision as of 17:17, 4 December 2012
ABL1, also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia.
Structure
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