SandboxPKA
From Proteopedia
(Difference between revisions)
| Line 16: | Line 16: | ||
=='''Catalitic domain'''== | =='''Catalitic domain'''== | ||
| - | <\ | + | <\load='3DY7' size='350' side='right' caption='ATP binding domain'> |
Aquí se sigue | Aquí se sigue | ||
Revision as of 17:20, 4 December 2012
ABL1, also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia.
Structure
| |||||||||||
Catalitic domain
<\load='3DY7' size='350' side='right' caption='ATP binding domain'>
Aquí se sigue
