4aot

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[[Image:4aot.png|left|200px]]
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==Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A==
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<StructureSection load='4aot' size='340' side='right' caption='[[4aot]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4aot]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AOT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GW8:1-(4-{METHYL[2-({4-[(METHYLSULFONYL)METHYL]PHENYL}AMINO)PYRIMIDIN-4-YL]AMINO}PHENYL)-3-{3-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]PHENYL}UREA'>GW8</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j7t|2j7t]], [[3zz2|3zz2]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aot RCSB], [http://www.ebi.ac.uk/pdbsum/4aot PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
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{{STRUCTURE_4aot| PDB=4aot | SCENE= }}
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==See Also==
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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===Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A===
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== References ==
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4aot]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AOT OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith, C]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Canning, P.]]
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[[Category: Canning, P]]
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[[Category: Delft, F Von.]]
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[[Category: Delft, F Von]]
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[[Category: Edwards, A.]]
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[[Category: Edwards, A]]
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[[Category: Elkins, J M.]]
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[[Category: Elkins, J M]]
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[[Category: Knapp, S.]]
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[[Category: Knapp, S]]
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[[Category: Liu, Y.]]
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[[Category: Liu, Y]]
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[[Category: Salah, E.]]
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[[Category: Salah, E]]
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[[Category: Szklarz, M.]]
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[[Category: Szklarz, M]]
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[[Category: Yue, W.]]
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[[Category: Yue, W]]
[[Category: Lok]]
[[Category: Lok]]
[[Category: Stk10]]
[[Category: Stk10]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 16:24, 9 December 2014

Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A

4aot, resolution 2.33Å

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