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2lx1

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[[Image:2lx1.png|left|200px]]
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==Major Conformation of the Internal Loop 5'GAGU/3'UGAG==
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<StructureSection load='2lx1' size='340' side='right' caption='[[2lx1]], [[NMR_Ensembles_of_Models | 19 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lx1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LX1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lx1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lx1 RCSB], [http://www.ebi.ac.uk/pdbsum/2lx1 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The RNA duplex, (5'GACGAGUGUCA)(2), has two conformations in equilibrium. The nuclear magnetic resonance solution structure reveals that the major conformation of the loop, 5'GAGU/3'UGAG, is novel and contains two unusual Watson-Crick/Hoogsteen GG pairs with G residues in the syn conformation, two A residues stacked on each other in the center of the helix with inverted sugars, and two bulged-out U residues. The structure provides a benchmark for testing approaches for predicting local RNA structure and a sequence that allows the design of a unique arrangement of functional groups and/or a conformational switch into nucleic acids.
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{{STRUCTURE_2lx1| PDB=2lx1 | SCENE= }}
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Novel conformation of an RNA structural switch.,Kennedy SD, Kierzek R, Turner DH Biochemistry. 2012 Nov 20;51(46):9257-9. doi: 10.1021/bi301372t. Epub 2012 Nov, 12. PMID:23134175<ref>PMID:23134175</ref>
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===Major Conformation of the Internal Loop 5'GAGU/3'UGAG===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_23134175}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2lx1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LX1 OCA].
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</StructureSection>
[[Category: Kennedy, S D.]]
[[Category: Kennedy, S D.]]
[[Category: Turner, D H.]]
[[Category: Turner, D H.]]

Revision as of 02:20, 29 September 2014

Major Conformation of the Internal Loop 5'GAGU/3'UGAG

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