4g35
From Proteopedia
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{{STRUCTURE_4g35| PDB=4g35 | SCENE= }} | {{STRUCTURE_4g35| PDB=4g35 | SCENE= }} | ||
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===Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.=== | ===Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.=== | ||
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{{ABSTRACT_PUBMED_22920569}} | {{ABSTRACT_PUBMED_22920569}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. | ||
==About this Structure== | ==About this Structure== | ||
[[4g35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA]. | [[4g35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022920569</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Drake, E.]] | [[Category: Drake, E.]] | ||
Revision as of 08:02, 30 June 2013
Contents |
Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.
Template:ABSTRACT PUBMED 22920569
Function
[MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
About this Structure
4g35 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Muppidi A, Doi K, Edwardraja S, Drake EJ, Gulick AM, Wang HG, Lin Q. Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors. J Am Chem Soc. 2012 Sep 12;134(36):14734-7. doi: 10.1021/ja306864v. Epub 2012 Sep, 4. PMID:22920569 doi:10.1021/ja306864v
