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1k1a

From Proteopedia

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[[Image:1k1a.png|left|200px]]
 
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{{STRUCTURE_1k1a| PDB=1k1a | SCENE= }}
{{STRUCTURE_1k1a| PDB=1k1a | SCENE= }}
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===Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family===
===Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family===
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{{ABSTRACT_PUBMED_11707390}}
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{{ABSTRACT_PUBMED_11707390}}
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==Disease==
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[[http://www.uniprot.org/uniprot/BCL3_HUMAN BCL3_HUMAN]] Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
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==Function==
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[[http://www.uniprot.org/uniprot/BCL3_HUMAN BCL3_HUMAN]] Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).<ref>PMID:8453667</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:011707390</ref><references group="xtra"/>
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<ref group="xtra">PMID:011707390</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cramer, P.]]
[[Category: Cramer, P.]]

Revision as of 22:05, 24 March 2013

Template:STRUCTURE 1k1a

Contents

Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family

Template:ABSTRACT PUBMED 11707390

Disease

[BCL3_HUMAN] Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.

Function

[BCL3_HUMAN] Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).[1]

About this Structure

1k1a is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Muller CW. Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. EMBO J. 2001 Nov 15;20(22):6180-90. PMID:11707390 doi:10.1093/emboj/20.22.6180
  1. ↑ Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell. 1993 Mar 12;72(5):729-39. PMID:8453667

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