1jsw

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[[Image:1jsw.png|left|200px]]
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==NATIVE L-ASPARTATE AMMONIA LYASE==
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<StructureSection load='1jsw' size='340' side='right' caption='[[1jsw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jsw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JSW FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_ammonia-lyase Aspartate ammonia-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.1 4.3.1.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jsw RCSB], [http://www.ebi.ac.uk/pdbsum/1jsw PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1jsw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray crystal structure of l-aspartate ammonia-lyase has been determined to 2.8 A resolution. The enzyme contains three domains, and each domain is composed almost completely of alpha helices. The central domain is composed of five long helices. In the tetramer, these five helices form a 20-helix cluster. Such clusters have also been seen in delta-crystallin and in fumarase. The active site of aspartase has been located in a region that contains side chains from three different subunits. The structure of the apoenzyme has made it possible to identify some of the residues that are involved in binding the substrate. These residues have been examined by site-directed mutagenesis, and their putative roles have been assigned [Jayasekera, M. M. K., Shi, W., Farber, G. K., &amp; Viola, R. E. (1997) Biochemistry 36, 9145-9150].
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{{STRUCTURE_1jsw| PDB=1jsw | SCENE= }}
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The structure of L-aspartate ammonia-lyase from Escherichia coli.,Shi W, Dunbar J, Jayasekera MM, Viola RE, Farber GK Biochemistry. 1997 Jul 29;36(30):9136-44. PMID:9230045<ref>PMID:9230045</ref>
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===NATIVE L-ASPARTATE AMMONIA LYASE===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_9230045}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1jsw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSW OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:009230045</ref><references group="xtra"/>
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[[Category: Aspartate ammonia-lyase]]
[[Category: Aspartate ammonia-lyase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]

Revision as of 09:08, 28 September 2014

NATIVE L-ASPARTATE AMMONIA LYASE

1jsw, resolution 2.70Å

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