1rlb
From Proteopedia
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| - | [[Image:1rlb.gif|left|200px]] | + | [[Image:1rlb.gif|left|200px]] |
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| - | '''RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN''' | + | {{Structure |
| + | |PDB= 1rlb |SIZE=350|CAPTION= <scene name='initialview01'>1rlb</scene>, resolution 3.1Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=REA:RETINOIC ACID'>REA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RLB is a [ | + | 1RLB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RLB OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein., Monaco HL, Rizzi M, Coda A, Science. 1995 May 19;268(5213):1039-41. PMID:[http:// | + | Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein., Monaco HL, Rizzi M, Coda A, Science. 1995 May 19;268(5213):1039-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7754382 7754382] |
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: complex (protein/protein)]] | [[Category: complex (protein/protein)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:53:12 2008'' |
Revision as of 11:53, 20 March 2008
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| , resolution 3.1Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN
Contents |
Overview
The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms. One tetramer of transthyretin was bound to two molecules of retinol-binding protein. The two retinol-binding protein molecules established molecular interactions with the same transthyretin dimer, and each also made contacts with one of the other two monomers. Thus, the other two potential binding sites in a transthyretin tetramer were blocked. The amino acid residues of the retinol-binding protein that were involved in the contacts were close to the retinol-binding site.
Disease
Known diseases associated with this structure: Amyloid neuropathy, familial, several allelic types OMIM:[176300], Amyloidosis, senile systemic OMIM:[176300], Carpal tunnel syndrome, familial OMIM:[176300], Dystransthyretinemic hyperthyroxinemia OMIM:[176300], Retinol binding protein, deficiency of OMIM:[180250]
About this Structure
1RLB is a Protein complex structure of sequences from Gallus gallus and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein., Monaco HL, Rizzi M, Coda A, Science. 1995 May 19;268(5213):1039-41. PMID:7754382
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