1rm6

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[[Image:1rm6.gif|left|200px]]<br /><applet load="1rm6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1rm6.gif|left|200px]]
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caption="1rm6, resolution 1.60&Aring;" />
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'''Structure of 4-hydroxybenzoyl-CoA reductase from Thauera aromatica'''<br />
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{{Structure
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|PDB= 1rm6 |SIZE=350|CAPTION= <scene name='initialview01'>1rm6</scene>, resolution 1.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene> and <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID'>EPE</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_reductase 4-hydroxybenzoyl-CoA reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.20 1.3.99.20]
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|GENE=
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}}
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'''Structure of 4-hydroxybenzoyl-CoA reductase from Thauera aromatica'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1RM6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thauera_aromatica Thauera aromatica] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=PCD:'>PCD</scene>, <scene name='pdbligand=FAD:'>FAD</scene>, <scene name='pdbligand=SF4:'>SF4</scene>, <scene name='pdbligand=FES:'>FES</scene> and <scene name='pdbligand=EPE:'>EPE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_reductase 4-hydroxybenzoyl-CoA reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.20 1.3.99.20] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RM6 OCA].
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1RM6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thauera_aromatica Thauera aromatica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RM6 OCA].
==Reference==
==Reference==
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Structure of a xanthine oxidase-related 4-hydroxybenzoyl-CoA reductase with an additional [4Fe-4S] cluster and an inverted electron flow., Unciuleac M, Warkentin E, Page CC, Boll M, Ermler U, Structure. 2004 Dec;12(12):2249-56. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15576037 15576037]
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Structure of a xanthine oxidase-related 4-hydroxybenzoyl-CoA reductase with an additional [4Fe-4S] cluster and an inverted electron flow., Unciuleac M, Warkentin E, Page CC, Boll M, Ermler U, Structure. 2004 Dec;12(12):2249-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576037 15576037]
[[Category: 4-hydroxybenzoyl-CoA reductase]]
[[Category: 4-hydroxybenzoyl-CoA reductase]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: b]]
[[Category: b]]
[[Category: c)2]]
[[Category: c)2]]
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[[Category: dimer heterotrimers]]
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[[Category: dimer heterotrimer]]
[[Category: xanthine oxidase family]]
[[Category: xanthine oxidase family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:53:32 2008''

Revision as of 11:53, 20 March 2008

Image:1rm6.gif


PDB ID 1rm6

Drag the structure with the mouse to rotate
, resolution 1.60Å
Ligands: , , , , , , , and
Activity: 4-hydroxybenzoyl-CoA reductase, with EC number 1.3.99.20
Coordinates: save as pdb, mmCIF, xml



Structure of 4-hydroxybenzoyl-CoA reductase from Thauera aromatica


Overview

The Mo-flavo-Fe/S-dependent heterohexameric protein complex 4-hydroxybenzoyl-CoA reductase (4-HBCR, dehydroxylating) is a central enzyme of the anaerobic degradation of phenolic compounds and belongs to the xanthine oxidase (XO) family of molybdenum enzymes. Its X-ray structure was established at 1.6 A resolution. The most pronounced difference between 4-HBCR and other structurally characterized members of the XO family is the insertion of 40 amino acids within the beta subunit, which carries an additional [4Fe-4S] cluster at a distance of 16.5 A to the isoalloxazine ring of FAD. The architecture of 4-HBCR and concomitantly performed electron transfer rate calculations suggest an inverted electron transfer chain from the donor ferredoxin via the [4Fe-4S] cluster to the Mo over a distance of 55 A. The binding site of 4-hydroxybenzoyl-CoA is located in an 18 A long channel lined up by several aromatic side chains around the aromatic moiety, which are proposed to shield and stabilize the postulated radical intermediates during catalysis.

About this Structure

1RM6 is a Protein complex structure of sequences from Thauera aromatica. Full crystallographic information is available from OCA.

Reference

Structure of a xanthine oxidase-related 4-hydroxybenzoyl-CoA reductase with an additional [4Fe-4S] cluster and an inverted electron flow., Unciuleac M, Warkentin E, Page CC, Boll M, Ermler U, Structure. 2004 Dec;12(12):2249-56. PMID:15576037

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