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1knz

From Proteopedia

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[[Image:1knz.png|left|200px]]
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==Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer==
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<StructureSection load='1knz' size='340' side='right' caption='[[1knz]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1knz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_rotavirus_a/sa11 Simian rotavirus a/sa11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KNZ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1knz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1knz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1knz RCSB], [http://www.ebi.ac.uk/pdbsum/1knz PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kn/1knz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rotaviruses, the cause of life-threatening diarrhea in humans and cattle, utilize a functional homolog of poly(A) binding protein (PABP) known as nonstructural protein 3 (NSP3) for translation of viral mRNAs. NSP3 binds to viral mRNA 3' consensus sequences and circularizes the mRNA via interactions with eIF4G. The X-ray structure of the NSP3 RNA binding domain bound to a rotaviral mRNA 3' end has been determined. NSP3 is a novel, heart-shaped homodimer with a medial RNA binding cleft. The homodimer is asymmetric, and contains two similar N-terminal segments plus two structurally different C-terminal segments that intertwine to create a tunnel enveloping the mRNA 3' end. Biophysical studies demonstrate high affinity binding leading to increased thermal stability and slow dissociation kinetics, consistent with NSP3 function.
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{{STRUCTURE_1knz| PDB=1knz | SCENE= }}
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Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer.,Deo RC, Groft CM, Rajashankar KR, Burley SK Cell. 2002 Jan 11;108(1):71-81. PMID:11792322<ref>PMID:11792322</ref>
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===Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11792322}}
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==See Also==
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*[[Nonstructural protein|Nonstructural protein]]
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==About this Structure==
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== References ==
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[[1knz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_rotavirus_a/sa11 Simian rotavirus a/sa11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KNZ OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011792322</ref><references group="xtra"/>
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[[Category: Simian rotavirus a/sa11]]
[[Category: Simian rotavirus a/sa11]]
[[Category: Burley, S K.]]
[[Category: Burley, S K.]]

Revision as of 14:21, 28 September 2014

Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer

1knz, resolution 2.45Å

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