1kug

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[[Image:1kug.png|left|200px]]
 
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{{STRUCTURE_1kug| PDB=1kug | SCENE= }}
{{STRUCTURE_1kug| PDB=1kug | SCENE= }}
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===Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with its endogenous inhibitor pENW===
===Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with its endogenous inhibitor pENW===
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{{ABSTRACT_PUBMED_12071970}}
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{{ABSTRACT_PUBMED_12071970}}
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==Function==
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[[http://www.uniprot.org/uniprot/VM2T3_PROMU VM2T3_PROMU]] Snake venom metalloproteinase TM-3: fibrin(ogen)olytic protease which cleaves the Aalpha chain of fibrinogen (FGA) first followed by the Bbeta chain (FGB) and shows relatively low activity on the gamma chain (FGG).<ref>PMID:8068721</ref> <ref>PMID:8193588</ref> Disintegrin trimucrin: inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).<ref>PMID:8068721</ref> <ref>PMID:8193588</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012071970</ref><references group="xtra"/>
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<ref group="xtra">PMID:012071970</ref><references group="xtra"/><references/>
[[Category: Atrolysin E]]
[[Category: Atrolysin E]]
[[Category: Protobothrops mucrosquamatus]]
[[Category: Protobothrops mucrosquamatus]]

Revision as of 08:15, 16 April 2014

Template:STRUCTURE 1kug

Contents

Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with its endogenous inhibitor pENW

Template:ABSTRACT PUBMED 12071970

Function

[VM2T3_PROMU] Snake venom metalloproteinase TM-3: fibrin(ogen)olytic protease which cleaves the Aalpha chain of fibrinogen (FGA) first followed by the Bbeta chain (FGB) and shows relatively low activity on the gamma chain (FGG).[1] [2] Disintegrin trimucrin: inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).[3] [4]

About this Structure

1kug is a 2 chain structure with sequence from Protobothrops mucrosquamatus. Full crystallographic information is available from OCA.

Reference

  • Huang KF, Chiou SH, Ko TP, Wang AH. Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues. Eur J Biochem. 2002 Jun;269(12):3047-56. PMID:12071970
  1. ↑ Tsai IH, Wang YM, Lee YH. Characterization of a cDNA encoding the precursor of platelet aggregation inhibition and metalloproteinase from Trimeresurus mucrosquamatus venom. Biochim Biophys Acta. 1994 Aug 18;1200(3):337-40. PMID:8068721
  2. ↑ Huang KF, Hung CC, Chiou SH. Characterization of three fibrinogenolytic proteases isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem Mol Biol Int. 1993 Dec;31(6):1041-50. PMID:8193588
  3. ↑ Tsai IH, Wang YM, Lee YH. Characterization of a cDNA encoding the precursor of platelet aggregation inhibition and metalloproteinase from Trimeresurus mucrosquamatus venom. Biochim Biophys Acta. 1994 Aug 18;1200(3):337-40. PMID:8068721
  4. ↑ Huang KF, Hung CC, Chiou SH. Characterization of three fibrinogenolytic proteases isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem Mol Biol Int. 1993 Dec;31(6):1041-50. PMID:8193588

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