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1muk

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[[Image:1muk.png|left|200px]]
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==reovirus lambda3 native structure==
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<StructureSection load='1muk' size='340' side='right' caption='[[1muk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1muk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MUK FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus sp.])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1muk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1muk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1muk RCSB], [http://www.ebi.ac.uk/pdbsum/1muk PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.
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{{STRUCTURE_1muk| PDB=1muk | SCENE= }}
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RNA synthesis in a cage--structural studies of reovirus polymerase lambda3.,Tao Y, Farsetta DL, Nibert ML, Harrison SC Cell. 2002 Nov 27;111(5):733-45. PMID:12464184<ref>PMID:12464184</ref>
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===reovirus lambda3 native structure===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12464184}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1muk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUK OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012464184</ref><references group="xtra"/>
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[[Category: Reovirus sp.]]
[[Category: Reovirus sp.]]
[[Category: Farsetta, D L.]]
[[Category: Farsetta, D L.]]

Revision as of 17:18, 28 September 2014

reovirus lambda3 native structure

1muk, resolution 2.50Å

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