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1m9o

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[[Image:1m9o.png|left|200px]]
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==NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11==
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<StructureSection load='1m9o' size='340' side='right' caption='[[1m9o]], [[NMR_Ensembles_of_Models | 23 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m9o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M9O FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nup475 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m9o RCSB], [http://www.ebi.ac.uk/pdbsum/1m9o PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m9/1m9o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required for rapid degradation of tumor necrosis factor (TNF) and other mRNAs through the interaction with AU-rich elements in their 3'-untranslated regions. The three-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding.
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{{STRUCTURE_1m9o| PDB=1m9o | SCENE= }}
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A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure.,Amann BT, Worthington MT, Berg JM Biochemistry. 2003 Jan 14;42(1):217-21. PMID:12515557<ref>PMID:12515557</ref>
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===NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12515557}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1m9o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012515557</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Amann, B T.]]
[[Category: Amann, B T.]]

Revision as of 17:32, 28 September 2014

NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11

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