1ngt
From Proteopedia
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| - | [[ | + | ==The Role of Minor Groove Functional Groups in DNA Hydration== |
| + | <StructureSection load='1ngt' size='340' side='right' caption='[[1ngt]], [[Resolution|resolution]] 2.04Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1ngt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NGT FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTR:(5-METHYL-6-OXO-1,6-DIHYDRO-PYRIDIN-3-YL)-1,2-DIDEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>MTR</scene></td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ngt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ngt RCSB], [http://www.ebi.ac.uk/pdbsum/1ngt PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove 'spine of hydration' is destabilized but essentially intact. | ||
| - | + | The role of minor groove functional groups in DNA hydration.,Woods KK, Lan T, McLaughlin LW, Williams LD Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:12595562<ref>PMID:12595562</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Lan, T.]] | [[Category: Lan, T.]] | ||
[[Category: McLaughlin, L W.]] | [[Category: McLaughlin, L W.]] | ||
Revision as of 17:53, 28 September 2014
The Role of Minor Groove Functional Groups in DNA Hydration
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