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1m23

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[[Image:1m23.png|left|200px]]
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==STRUCTURE OF THE DIMERIZED CYTOPLASMIC DOMAIN OF P23 IN SOLUTION==
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<StructureSection load='1m23' size='340' side='right' caption='[[1m23]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m23]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M23 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m23 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m23 RCSB], [http://www.ebi.ac.uk/pdbsum/1m23 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Coatomer, the coat protein complex of COPI vesicles, is involved in the budding of these vesicles, but the underlying mechanism is unknown. Toward a better understanding of this process, the interaction between coatomer and the cytoplasmic domain of a major transmembrane protein of COPI vesicles, p23, was studied. Interaction of coatomer with this peptide domain results in a conformational change and polymerization of the complex in vitro. This changed conformation also is observed in vivo, i.e., on the surface of authentic, isolated COPI vesicles. An average of four peptides was found associated with one coatomer complex after polymerization. Based on these results, we propose a mechanism by which the induced conformational change of coatomer results in its polymerization, and thus drives formation of the bud on the Golgi membrane during biogenesis of a COPI vesicle.
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{{STRUCTURE_1m23| PDB=1m23 | SCENE= }}
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Receptor-induced polymerization of coatomer.,Reinhard C, Harter C, Bremser M, Brugger B, Sohn K, Helms JB, Wieland F Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1224-8. PMID:9990005<ref>PMID:9990005</ref>
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===STRUCTURE OF THE DIMERIZED CYTOPLASMIC DOMAIN OF P23 IN SOLUTION===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_9990005}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1m23]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M23 OCA].
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</StructureSection>
[[Category: Reinhard, C.]]
[[Category: Reinhard, C.]]
[[Category: Roesch, P.]]
[[Category: Roesch, P.]]

Revision as of 15:04, 28 September 2014

STRUCTURE OF THE DIMERIZED CYTOPLASMIC DOMAIN OF P23 IN SOLUTION

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