1s1j
From Proteopedia
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| - | [[Image:1s1j.jpg|left|200px]] | + | [[Image:1s1j.jpg|left|200px]] |
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| - | '''Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1''' | + | {{Structure |
| + | |PDB= 1s1j |SIZE=350|CAPTION= <scene name='initialview01'>1s1j</scene>, resolution 2.18Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=IQZ:(7AS,12AR,12BS)-1,2,3,4,7A,12,12A,12B-OCTAHYDROINDOLO[2,3-A]QUINOLIZIN-7(6H)-ONE'>IQZ</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= ZIPA, B2412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1S1J is a [ | + | 1S1J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1J OCA]. |
==Reference== | ==Reference== | ||
| - | Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:[http:// | + | Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15006376 15006376] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: cell cycle]] | [[Category: cell cycle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:59:10 2008'' |
Revision as of 11:59, 20 March 2008
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| , resolution 2.18Å | |||||||
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| Ligands: | |||||||
| Gene: | ZIPA, B2412 (Escherichia coli) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1
Overview
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.
About this Structure
1S1J is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:15006376
Page seeded by OCA on Thu Mar 20 13:59:10 2008
