1l1w

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[[Image:1l1w.png|left|200px]]
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==NMR structure of a SRP19 binding domain in human SRP RNA==
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<StructureSection load='1l1w' size='340' side='right' caption='[[1l1w]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l1w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1W FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l1w RCSB], [http://www.ebi.ac.uk/pdbsum/1l1w PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Assembly of the human signal recognition particle (SRP) requires SRP19 protein to bind to helices 6 and 8 of SRP RNA. In the present study, structure of a 29-mer RNA composing the SRP19 binding site in helix 6 was determined by NMR spectroscopy. The two A:C mismatches were continuously stacked to each other and formed wobble type A:C base pairs. The GGAG tetraloop in helix 6 was found to adopt a similar conformation to that of GNRA tetraloop, suggesting that these tetraloops are included in an extensive new motif GNRR. Compared with the crystal structure of helix 6 in complex with SRP19 determined previously, the GGAG tetraloop in the complex was found to adopt a similar conformation to the free form, although the loop structure becomes more open upon SRP19 binding. Thus, SRP19 is thought to recognize the overall fold of the GGAG loop.
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{{STRUCTURE_1l1w| PDB=1l1w | SCENE= }}
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Solution structure of a SRP19 binding domain in human SRP RNA.,Sakamoto T, Morita S, Tabata K, Nakamura K, Kawai G J Biochem. 2002 Aug;132(2):177-82. PMID:12153712<ref>PMID:12153712</ref>
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===NMR structure of a SRP19 binding domain in human SRP RNA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12153712}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1l1w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA].
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</StructureSection>
[[Category: Kawai, G.]]
[[Category: Kawai, G.]]
[[Category: Morita, S.]]
[[Category: Morita, S.]]

Revision as of 18:21, 28 September 2014

NMR structure of a SRP19 binding domain in human SRP RNA

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