1s4j
From Proteopedia
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| - | [[Image:1s4j.gif|left|200px]] | + | [[Image:1s4j.gif|left|200px]] |
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| - | '''NMR structure of cross-reactive peptides from Homo sapiens''' | + | {{Structure |
| + | |PDB= 1s4j |SIZE=350|CAPTION= <scene name='initialview01'>1s4j</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''NMR structure of cross-reactive peptides from Homo sapiens''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1S4J is a [ | + | 1S4J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4J OCA]. |
==Reference== | ==Reference== | ||
| - | Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis., Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC, FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:[http:// | + | Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis., Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC, FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14988012 14988012] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Almeida, F C.L.]] | [[Category: Almeida, F C.L.]] | ||
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[[Category: ribosomal p2 protein]] | [[Category: ribosomal p2 protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:00:20 2008'' |
Revision as of 12:00, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR structure of cross-reactive peptides from Homo sapiens
Overview
The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid difference between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2beta protein was probed by transferred NOE. The results show that the flexibility of R13 is fundamental for the binding to the antibody.
About this Structure
1S4J is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis., Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC, FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:14988012
Page seeded by OCA on Thu Mar 20 14:00:20 2008
