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1k9g
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| - | [[ | + | ==Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2== |
| + | <StructureSection load='1k9g' size='340' side='right' caption='[[1k9g]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1k9g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K9G FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DR1:5-METHYL-5H-INDOLO[3,2-B]QUINOLINE'>DR1</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k9g RCSB], [http://www.ebi.ac.uk/pdbsum/1k9g PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites. Here we show that cryptolepine interacts with the CC sites of the DNA fragment d(CCTAGG)(2) in a base-stacking intercalation mode. This is the first DNA intercalator complex, from approximately 90 solved by X-ray crystallography, to bind a nonalternating (pyrimidine-pyrimidine) DNA sequence. The asymmetry of the drug induces a perfect stacking with the asymmetric site, allowing for the stability of the complex in the absence of hydrogen bonding interactions. The crystal structure of this antimalarial drug-DNA complex provides evidence for the first nonalternating intercalation and, as such, provides a basis for the design of new anticancer or antimalarial drugs. | ||
| - | + | The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites.,Lisgarten JN, Coll M, Portugal J, Wright CW, Aymami J Nat Struct Biol. 2002 Jan;9(1):57-60. PMID:11731803<ref>PMID:11731803</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Aymami, J.]] | [[Category: Aymami, J.]] | ||
[[Category: Coll, M.]] | [[Category: Coll, M.]] | ||
Revision as of 14:40, 28 September 2014
Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2
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