Sandox Bay Serrano
From Proteopedia
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== Introduction == | == Introduction == | ||
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| + | Caspases are '''c'''ysteine-'''asp'''artic acid prote'''ases''' and are key protein facilitators for the faithful execution of apoptosis or programmed cell death. Because of the crucial role of caspases in the the apoptotic pathway, any dysregulation in their functions would be deleterious to the cell. | ||
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</StructureSection> | </StructureSection> | ||
| - | <StructureSection load='2h5i_mm1-1.pdb' size='350' side='right' caption='Caspase-3 dimer (PDB entry [[2h5i]])' scene='Sandox_Bay_Serrano/Scene01_dimer/1 | + | <StructureSection load='2h5i_mm1-1.pdb' size='350' side='right' caption='Caspase-3 dimer (PDB entry [[2h5i]])' scene='Sandox_Bay_Serrano/Scene01_dimer/1'> |
'''Caspase-3 Structure''' | '''Caspase-3 Structure''' | ||
| - | Caspases are synthesized in the cell in their zymogen forms, consisting of an N-terminal prodomain followed by a large and | + | Caspases are synthesized in the cell in their zymogen forms, consisting of an N-terminal prodomain followed by a <scene name='Sandox_Bay_Serrano/Dimer_gray/1'>large and small subunit</scene> linked to each other by an intersubunit linker. As an executioner caspase, caspase-3 has a short N-terminal prodomain and like any other caspases, cleavage of the intersubunit linker at a specific aspartate residue generates the mature form of the enzyme. Caspase-3 in its functional form is dimeric, with the dimer interface being stabilized by interactions between the small subunits of each monomer. Binding of a <scene name='Sandox_Bay_Serrano/Scene01_substrate/2'>substrate</scene>, such as DEVD-CHO to the active site of the enzyme induces a conformational change that allows the L2 and L2' loops to interlock and stabilize the active site <scene name='Sandox_Bay_Serrano/Scene01_substrate/3'></scene>. |
Revision as of 19:16, 12 December 2012
Introduction
Caspases are cysteine-aspartic acid proteases and are key protein facilitators for the faithful execution of apoptosis or programmed cell death. Because of the crucial role of caspases in the the apoptotic pathway, any dysregulation in their functions would be deleterious to the cell.
</StructureSection>
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