4hwi

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'''Unreleased structure'''
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{{STRUCTURE_4hwi| PDB=4hwi | SCENE= }}
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===Crystal structure of ATBAG1 in complex with HSP70===
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{{ABSTRACT_PUBMED_23695238}}
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The entry 4hwi is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> [[http://www.uniprot.org/uniprot/BAG1_ARATH BAG1_ARATH]] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity).
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Authors: Shen, Y., Fang, S.
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==About this Structure==
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[[4hwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWI OCA].
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Description: Crystal structure of ATBAG1 in complex with HSP70
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==Reference==
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<ref group="xtra">PMID:023695238</ref><references group="xtra"/><references/>
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[[Category: Arabidopsis thaliana]]
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[[Category: Homo sapiens]]
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[[Category: Fang, S.]]
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[[Category: Shen, Y.]]
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[[Category: Bag domain]]
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[[Category: Chaperone-apoptosis complex]]
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[[Category: Co-chaperone]]
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[[Category: Complex with molecular chaperone]]
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[[Category: Ubiquitin-like domain]]

Revision as of 07:57, 19 June 2013

Template:STRUCTURE 4hwi

Contents

Crystal structure of ATBAG1 in complex with HSP70

Template:ABSTRACT PUBMED 23695238

Function

[HSP7C_HUMAN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.[1] [BAG1_ARATH] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity).

About this Structure

4hwi is a 2 chain structure with sequence from Arabidopsis thaliana and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Fang S, Li L, Cui B, Men S, Shen Y, Yang X. Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):934-45. doi:, 10.1107/S0907444913003624. Epub 2013 May 2. PMID:23695238 doi:10.1107/S0907444913003624
  1. ↑ Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, Isselbacher KJ, Shioda T. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000 Mar 24;275(12):8825-34. PMID:10722728

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